Detected as a riboswitch by 20 out of 20 classifiers
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5HSAA036089 Similarity: 0.896 Similarity: 0.892 Similarity: 0.891
UTR: 5HSAA036089
Gene: EPHA7
MFE: -57.927
ENS: 0.962
Length: 266.
Predicted Ligands:
cobalamin - 18/20
glucosamine - 1/20
FMN - 1/20
 RS: URS0002328AE2_1004785
MFE: -70.589
Ligand: cobalamin
Species: Alteromonas macleodii str. 'Black Sea 11' Cobalamin riboswitch
 RS: URS000231E47C_651661
MFE: -81.485
Ligand: cobalamin
Species: Dyadobacter sp. BZ26 Cobalamin riboswitch
 RS: URS0000C7EF93_747377
MFE: -64.399
Ligand: cobalamin
Species: Clostridium sp. DMHC 10 Cobalamin riboswitch
image of 5prime UTR secondary structure image of the secondary structure of the first Riboswitch match image of the secondary structure of the second Riboswitch match image of the secondary structure of the third Riboswitch match
circular plot of the 5prime UTR base pairs circular plot of the 5prime UTR base pairs compared with the first Riboswitch base pairs circular plot of the 5prime UTR base pairs compared with the second Riboswitch base pairs circular plot of the 5prime UTR base pairs compared with the third Riboswitch base pairs
line plot comparing the structural features of the 5prime UTR with its first riboswitch match line plot comparing the structural features of the 5prime UTR with its second riboswitch match line plot comparing the structural features of the 5prime UTR with its third riboswitch match
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heatmap comparing sequence features of the 5prime UTR and top three riboswitch matches
Heatmap of base pair probabilities for 1000 computational NUPACK foldings of the 5prime UTR
Heatmap of base pair probabilities for computational NUPACK foldings of the 5prime UTR that leave the start codon unbound
Heatmap of base pair probabilities for computational NUPACK foldings of the 5prime UTR that leave the start codon bound
Heatmap of base pair probabilities for computational NUPACK foldings of the 5prime UTR with the bound and unbound conformers overlaid
ML ensemble output for the 5prime UTR

Information

  5’UTR RS match 1 RS match 2 RS match 3
Link - RNAcentral RNAcentral RNAcentral
ID 5HSAA036089 URS0002328AE2_1004785 URS000231E47C_651661 URS0000C7EF93_747377
Length 266. 266. 264. 267.
Similarity - 0.896 0.892 0.891
Ensemble Norm 0.962 - - -
MFE -57.927 -70.589 -81.485 -64.399
Ligands - cobalamin cobalamin cobalamin
Gene EPHA7 - - -
Downstream protein Genecard - - -

Similarity metrics

  5’UTR RS match 1 RS match 2 RS match 3
Struct SE - 16.005 29.007 20.005
Length SE - 0. 4. 1.
Lev Distance - 130. 119. 131.
UBS 14. 17. 16. 17.
BS 0. 0. 0. 0.
ILL 4. 5. 6. 6.
ILR 4. 5. 4. 6.
H 4. 5. 6. 5.
BL 5. 5. 4. 6.
BR 6. 4. 2. 5.
UN 0.150 0.083 0.068 0.082

Sequences

Field Description
UTR seq + 25 auuggaguguggagcaagcggccggucugcagucggagacuugcaggcagcaaacacggugcgagcgaacaggagugggggggaaauuaaaaaaagcuaaacguggagcagccgaucggggaccgagaaggggaaucgaugcaaggagcacaauaaaacaaaagcuacuucggaacaaacagcauuuaaaaauccacgacucaagauaacugaaaccuaaaauaaaaccugcucaugcaccATGGTTTTTCAAACTCGGTACCCTT
UTR dot + 25 .((.((.((((((.(……..).)))))).)).))…((((..(((.(……).)))..))))………………………(((……..)))……..((((((((((..(((((((((.((((..(((((………………(((((………………………………)))))……………))))).))))…)))))))))…)))))).)))).
RS 1 seq UAUAAUCGAUGGCGUGUAGGUGCUCUUGUCUAACGCCAUAUUAACUACGGUGACAAGGGUUAAACGGGAAAUCAGUGAAAAGCUGAUGCUGCCCCCGCAACGGUAAACUCAACGCAUUGUCGUUUUCUUUUCAUACGCCACUGUCUUUUAUACGUUUACGCGCGCUCCUGCGUAGCUAAACGCCAAUAGAUGGGAAGGCAAAAGAGCCAUUACAUACUUGGUAAUGGUGAGUAAGCCCGGAUACCGGCCUGUACUUCAUGGUGUCG
RS 1 dot ……..(((((((.((((……..)))))))))))…(((.((((((….(((((…((((..((((((…..))))))……))))……..)))))….)))))).)))(((((((…..(((.((((((……((((((.((((((….)))).))))))))…..))))))…))))))))))(((((((…….))))))).(((((((.((((…)))).)).)))))……….
RS 2 seq CAUCUUUGCGGCUCAAUUGGUUUGCGCCUUUGGGCGUGAUGAAAAGGGAAUCCGGUGAAAAUCCGGAGCAGUACCCGCUGCUGUAAGUUCAUAAUGAAGCGUUGCAACAAGUUUGUGCCACUGGGAAGAAAUUUGAAUGAGUGAAUGAAUGAAUGAAUAAUAAAACAUUCACUCAUUCAAUCAUUCACUCAUUCACUCAUUAAUCACCCGGGAAGGCGUUGCGACGGAACGAGCCAGAAGACCUGCCAGUCGAUAUUUUAUCCG
RS 2 dot ((((…((.((((((..(((….))).))))))))))))……….((((…….))))((((((….))))))((..((((………(((((((((……..(((.(((((….(((.(((((((((((((((.(((((((…………….))))))).)))))))))))))))…)))…..)))))…))))))))))))))))..))(((…..)))……((((…))))..
RS 3 seq AAGGGAAUGUGGUAUAUGCCACAGCAGCCCCCGCUACUGUAAUCAUAGACGAAUGAUUUGUAGGUAUAUGGUGGAACCACCGUAAAACUAAUCUAUUUAUGUUCUAAAAUCCUAAUUUUUAAGGAAUUAUGUACAUAUAUAGAUUUUACUUGAGCUGGUUUCAAUGAGUAUAUCUUUAACGCCACUCAUUUUUAAGGUGAUUUCUAUAGUAAUUAUCUUAAUUUGGGGAAGGUAAAUCAUGAGGAUGAAGUGAAAGCCAGGAUAUCU
RS 3 dot ..(((..((((((….))))))….)))…((((…((((((……)))))).))))((.(((((((….)))))))..)).(((((((.(((((…….((((……..))))…….))))).)))))))………(((((((…(.(.(.((((((((..(((.((((…(((((((((((……..)))))))))))..))))…)))……)))))))).).).))))))))…….

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